RAP-103
RAP-103 is an orally active CCR antagonist that provides potent synaptic protection by inhibiting and reversing cytoskeletal changes induced by PrPC/NOX signaling. RAP-103 is potentially useful in Alzheimer's disease (AD) research[1].
Product Specifications
CAS Number
[1337998-99-8]
UNSPSC
12352209
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
C[C@H](O)[C@H](C(O)=O)NC([C@@H](CC1=CC=C(O)C=C1)NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](O)C)NC([C@@H]([C@@H](O)C)N)=O)=O)=O)=O
Molecular Formula
C25H38N6O11
Molecular Weight
598.60
References & Citations
[1]Kuhn TB, et al. Chemokine Receptor Antagonists Prevent and Reverse Cofilin-Actin Rod Pathology and Protect Synapses in Cultured Rodent and Human iPSC-Derived Neurons. Biomedicines. 2024 Jan 1;12 (1) :93.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P11319/
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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