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DBCO-tag peptide P1

DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab (HY-P9907) ) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research[1].

Product Specifications

UNSPSC

12352209

Target

Biochemical Assay Reagents; Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related; Others

Field of Research

Others

Smiles

O=C(N[C@@H](CS)C(N[C@@H](CC1=CC=C(C=C1)O)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C(C)C)C(N[C@@H](CC5=CC=C(C=C5)O)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Molecular Formula

C48H62N8O10S

Molecular Weight

943.12

References & Citations

[1]Zhang C, et al. Site-Selective Cysteine-Cyclooctyne Conjugation. Angew Chem Int Ed Engl. 2018 May 28;57 (22) :6459-6463.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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