Cys-GE11
Cys-GE11 is a short peptide modified with cysteine. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells) . Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity[1].
Product Specifications
CAS Number
[1421680-54-7]
UNSPSC
12352209
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H]([C@H](O)C)C(N7[C@@H](CCC7)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
Molecular Formula
C78H102N18O20S
Molecular Weight
1643.82
References & Citations
[1]Zhou C, et al. GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma. Acta Biomater. 2020 Sep 1;113:512-521.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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