Biotin- (Oaa) 3-epoxomicin

Biotin- (Oaa) 3-epoxomicin (Compound 13) is a biotinylated active form of Epoxomicin (HY-13821) . Biotin- (Oaa) 3-epoxomicin is a high affinity probe targeting Proteasome. Biotin- (Oaa) 3-epoxomicin covalently binds to multiple proteasome catalytic subunits (such as LMP7, Z and MECL1) [1].

Product Specifications

CAS Number

[247068-92-4]

UNSPSC

12352209

Target

Proteasome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

O=C([C@]1(CO1)C)[C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)N(C)C(CCCCCNC(CCCCCNC(CCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C54H95N9O11S

Molecular Weight

1078.45

References & Citations

[1]Sin N, et al. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett. 1999 Aug 2;9 (15) :2283-8.