AC-SDKP-NH2

AC-SDKP-NH2 is a substrate peptide of Angiotensin converting enzyme (ACE) . AC-SDKP-NH2 has anti-inflammatory and anti-fibrotic activities. AC-SDKP-NH2 directly acts on tissues and prevents or reverses them from excessive fibrosis, but fails to reduce blood pressure and left ventricular hypertrophy (LVH) . AC-SDKP-NH2 attenuates inflammation and cell differentiation, proliferation and migration, therefore reducing fibrosis in the heart, vessels and kidneys in mice model. AC-SDKP-NH2 can be used for cardiovascular diseases such as hypertension research[1].

Product Specifications

CAS Number

194484-75-8

UNSPSC

12352209

Target

Angiotensin-converting Enzyme (ACE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CC(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N)=O)=O)=O)=O)=O

Molecular Formula

C20H34N6O8

Molecular Weight

486.52

References & Citations

[1]Hrenak J, et al. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) : Potential target molecule in research of heart, kidney and brain. Curr Pharm Des. 2015;21 (35) :5135-43.