NNC0165-1273
NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36) . NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research[1].
Product Specifications
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Smiles
NC(NCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@@H](N)[C@H](CC)C)=O)CCCCN)=O)=O)CCC(O)=O)=O)C)=O)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)C)=O)CO)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC4=CC=C(O)C=C4)=O)CC5=CC=C(O)C=C5)=O)C)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC6=CNC=N6)=O)CC7=CC=C(O)C=C7)=O)CC(C)C)=O)CC(N)=O)=O)CC8=CNC9=CC=CC=C98)=O)C(C)C)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(N[C@H](C(N)=O)CC%10=CC=C(O)C=C%10)=O)=N
Molecular Formula
C186H280N54O54
Molecular Weight
4136.54
References & Citations
[1]Jones ES, et al. Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice. Endocrinology. 2019 Nov 1;160 (11) :2737-2747.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NPY Y2 receptor
Frequently Asked Questions
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