Intermedin1-53 (Human)

Intermedin1-53 (Human) is a 53-aa human calcitonin family peptide that reduces the vulnerability of atherosclerotic plaques by inhibiting CHOP-mediated macrophage apoptosis and inflammasome[1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Smiles

O=C(N[C@@H](CO)C(NCC(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(NCC(N5[C@@H](CCC5)C(N[C@@H](C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](C)C(N6[C@@H](CCC6)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N7[C@@H](CCC7)C(N[C@@H](CO)C(N[C@@H](CO)C(N8[C@@H](CCC8)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CO)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%11=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@H]%11[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%12=CNC=N%12)N

Molecular Formula

C247H395N83O73S3

Molecular Weight

5791.49

References & Citations

[1]Ren JL, et al. Intermedin1-53 attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages. Cell Death Dis. 2021 May 1;12 (5) :436.