YQGN-7
YQGN-7 is a targeted fluorescent probe for the gonadotropin-releasing hormone receptor (RnRHR) . YQGN-7 exhibits high selectivity and affinity for breast cancer cells (KD = 217.8 nM) . YQGN-7 achieves precise visualization of the primary and metastatic lesions of breast cancer by targeting the highly expressed GnRHR in tumor cells. YQGN-7 can be used in the research of breast cancer breast-conserving surgery (BCS) [1].
Product Specifications
UNSPSC
12352209
Target
Fluorescent Dye; GnRH Receptor
Related Pathways
GPCR/G Protein; Others
Field of Research
Cancer
Smiles
O=C(C1NC(CC1)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(N2C(CCC2)C(NCC)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCCNC(CCCCCNC(CCSC3=C(CCC/C3=C\C=C4N(C5=C(C\4(C)C)C=C(S(=O)(O)=O)C=C5)CCCS(=O)(O)=O)/C=C/C6N(C7=C(C6(C)C)C=C(C=C7)S(=O)(O)=O)CCCS(=O)(O)=O)=O)=O)=O)CC8=CC=C(C=C8)O)=O)CO)=O)CC9=CNC%10=C9C=CC=C%10)=O)CC%11=CNC=N%11
Molecular Formula
C104H144N20O26S5
Molecular Weight
2250.70
References & Citations
[1]Xu H, et al. Repurposing GnRH-A as a Near-Infrared Fluorescent Probe for Diagnosis and Surgical Navigation of Breast Cancer Tumors and Metastases. J Med Chem. 2024 Jul 25;67 (14) :12386-12398.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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