GUB021794

GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC50 value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC50 value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes[1].

Product Specifications

UNSPSC

12352209

Target

GLP Receptor

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease

Smiles

[H]N[C@H](C(NC(C)(C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CC(C)C)=O)CC1=CNC=N1)=O)CCC(O)=O)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)=O)CC(C)C)=O)CC3=CC=C(C=C3)O)=O)CO)=O)C(C)C)=O)CC(O)=O)=O)CO)=O)[C@H](O)C)=O)CC4=CC=CC=C4)=O)[C@H](O)C)=O)=O)CCC(O)=O)=O)C)=O)CC5=CNC=N5

Molecular Formula

C178H282N40O55

Molecular Weight

3862.38

References & Citations

[1]Nielsen JC, et al. Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties. J Med Chem. 2024 Jul 25;67 (14) :11814-11826.