PDI
PDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC50s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer[1].
Product Specifications
CAS Number
1443628-44-1
UNSPSC
12352209
Target
MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Molecular Formula
C71H99N17O19
Molecular Weight
1494.65
References & Citations
[1]Xu L, et al. Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo. J Med Chem. 2024 Oct 10;67 (19) :17893-17904. |[2]Hu B, et al. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67 (18) :8810-7.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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