DOTA-Bn-CA-170

DOTA-Bn-CA-170 is a molecular probe targeting the VISTA protein, with a Kd value of 0.124 nM. DOTA-Bn-CA-170 is formed by covalently linking the p-SCN-Bn-DOTA ligand with CA-170 (HY-101093) . DOTA-Bn-CA-170 labeled with [68Ga]Ga successfully achieves specific and high-contrast PET imaging of VISTA expression in various tumor-bearing mouse models. DOTA-Bn-CA-170 can be used for the study of VISTA-targeted immunotherapy[1].

Product Specifications

UNSPSC

12352209

Target

VISTA

Field of Research

Inflammation/Immunology

Smiles

O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CCC(NCC2=CC=C(C=C2)NC(N[C@@H](CO)C3=NOC([C@H](CC(N)=O)NC(N[C@H](C(O)=O)[C@@H](C)O)=O)=N3)=S)=O)O

Molecular Formula

C37H56N12O14S

Molecular Weight

924.98

References & Citations

[1]Liu J, et al. Small-Molecule Radiotracers for Visualization of V-Domain Immunoglobulin Suppressor of T Cell Activation. J Med Chem. 2024 Oct 10;67 (19) :17690-17700.