Mr1.1[S4Dap, C16Pen]
Mr1.1[S4Dap, C16Pen] is a highly active and selective nAChR (human α9α10 nAChR IC50 = 4.0 nM, rat α9α10 nAChR IC50 = 2.7 nM) inhibitor. Mr1.1[S4Dap, C16Pen] can significantly relieve pain and has significant stability. Mr1.1[S4Dap, C16Pen] can be used for the study of neuropathic pain[1].
Product Specifications
UNSPSC
12352209
Target
NAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C([C@@H](N)CC1=CNC=N1)NCC(N[C@H](C(N[C@H](C(NC[C@H](C(N[C@H](C(N2[C@H](C(N[C@H]3C)=O)CCC2)=O)CC4=CNC=N4)=O)CSSC(C)(C)[C@@H](C(N)=O)NC5=O)=O)CN)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H]5[C@H](CC)C)=O)CC(O)=O)=O)CCC6)=O)CC(N)=O)=O)CC(N)=O)=O)C(C)C)=O)CO)=O)NC3=O)=O
Molecular Formula
C71H109N25O22S4
Molecular Weight
1793.04
References & Citations
[1]Li T, et al. Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain. J Med Chem. 2024 Nov 14;67 (21) :18741-18752.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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