A13:B7-24-GG
A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation[1].
Product Specifications
CAS Number
3057097-31-8
UNSPSC
12352209
Target
RXFP Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
[H]N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C)C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(O)=O)CSSC[C@H](N1)C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O)=O)CCCNC(N)=N)=O)CO)=O)=O)=O)=O)CC(C)C)=O)=O)CO)=O)CC(C)C)=O)=O)CCCCN)=O)=O)CO)=O)=O)=O)=O)[C@@H](C)O)=O)CSSC[C@H](N[H])C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H]([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H]([C@H](CC)C)C1=O)=O)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O
Molecular Formula
C149H236N40O47S5
Molecular Weight
3500.03
References & Citations
[1]Wang MD, et al. Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death. J Am Chem Soc. 2024 Oct 23;146 (42) :28669-28676.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15243891 1 Vial
Lentiviral mouse Uhrf2 shRNA (UAS) - Lentiviral mouse Uhrf2 shRNA (UAS, iRFP) (100)
Sign In for Pricing
View Details 
K3429603 1.0 µg DNA
Ccdc96 sgRNA CRISPR Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details PC103053-01 100 mg
(2S) -tert-Butyl 4,4-difluoro-2-formylpyrrolidine-1-carboxylate
Sign In for Pricing
View Details PC103053-02 250 mg
(2S) -tert-Butyl 4,4-difluoro-2-formylpyrrolidine-1-carboxylate
Sign In for Pricing
View Details