NN1213 (acetate)
NN1213 acetate (Peptide 21), a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with an EC50 of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 acetate significantly reduces appetite in rat and dog models. NN1213 acetate can be used for antiobesity research[1].
Product Specifications
UNSPSC
12352209
Target
Amylin Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O)=O.O=C([C@H](CCCCNC(CC[C@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)C(O)=O)=O)N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=C(O)C=C4)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CO)=O)=O)C(C)C)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)CO)=O)CCC3)=O)[C@H](CC)C)=O)C)=O)=O)CC5=CC=CC=C5)=O)CC(N)=O)=O)CCC2)=O)CO)=O)CO)=O)CC6=CNC=N6)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC7=CC=CC=C7)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)O)=O)C)=O.[x]
Molecular Formula
C198H316N56O63S2.xC2H4O2
Molecular Weight
4553.10 (free base)
References & Citations
[1]Dahl K, et al. NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. J Med Chem. 2024 Jul 25;67 (14) :11688-11700. doi: 10.1021/acs.jmedchem.4c00022. Epub 2024 Jul 3. Erratum in: J Med Chem. 2024 Dec 26;67 (24) :22342.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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