Dpep24

Dpep24 is a highly selective and affinity cyclic D-type sulfated peptide inhibitor. Dpep24 can target and inhibit the inflammatory chemokine CCL22 (KD = 190 nM) . Dpep24 can be used for research on inflammatory conditions[1].

Product Specifications

UNSPSC

12352209

Target

CCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(N1[C@H](CCC1)C(N[C@H](CCC(N)=O)C(N[C@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@H](CCC(O)=O)C(N[C@H](CC2=CC=C(OS(=O)(O[Na])=O)C=C2)C(N[C@H](CC3=CC=C(C=C3)O)C(N[C@H](CCCCN)C(N[C@H](C(C)C)C(N[C@H](CCCCN)C(N[C@H](CCC(O)=O)C(N4[C@@H]5CCC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC(C)C)NOC5=O

Molecular Formula

C76H114N17NaO26S

Molecular Weight

1736.87

References & Citations

[1]Zhang BB, et al. Discovery of Selective Cyclic d-Sulfopeptide Ligands of the Chemokine CCL22 via Mirror-Image mRNA Display with Genetic Reprogramming. J Am Chem Soc. 2024 Dec 18;146 (50) :34253-34259.