Hydrostatin-TL1

Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research[1].

Product Specifications

CAS Number

[2243975-43-9]

Product Name Alternative

H-TL1

UNSPSC

12352209

Target

ERK; Integrin; Interleukin Related; JNK; NF-κB; p38 MAPK; TNF Receptor

Related Pathways

Apoptosis; Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C39H71N11O13S

Molecular Weight

934.11

References & Citations

[1]Wang N, et al. Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea. Int J Mol Sci. 2016 Nov 22;17 (11) :1940.