MAGE-A4 (286-294)

MAGE-A4 (286-294) is a polypeptide derived from the 286th to 294th amino acids of the MAGE-A4 protein. MAGE-A4 (286-294) binds HLA-A*02 with an affinity of 560.08 nM and an IC50 of 8.52 nM. MAGE-A4 (286-294) can be detected in various types of cancers (such as esophageal cancer, lung squamous cell carcinoma, bladder cancer) . MAGE-A4 (286-294) can be used to produce CAR-T cells and to develop CAR-T cell therapy[1].

Product Specifications

CAS Number

[289905-22-2]

UNSPSC

12352209

Target

Others

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Molecular Formula

C49H87N15O12

Molecular Weight

1078.31

References & Citations

[1]Salzler R, et al. CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo. Sci Transl Med. 2025 Mar 26;17 (791) :eado9371.