MBP (111-129)

MBP (111-129) is a polypeptide that constitutes an immunodominant epitope cluster restricted by HLA-DRB1*0401. MBP (111-129) is an antagonist for the clone HD4-1C2 TCR and an agonist for clone MS2-3C8 TCR. MBP (111-129) can be used for on multiple sclerosis and T cell biology[1].

Product Specifications

CAS Number

[178328-64-8]

UNSPSC

12352209

Target

MHC; Transmembrane Glycoprotein

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(NCC(N[C@@H](CC5=CC=CC=C5)C(NCC(N[C@@H](CC6=CC=C(C=C6)O)C(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Molecular Formula

C92H129N27O26

Molecular Weight

2029.17

References & Citations

[1]Kawamura K, et al. Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery. J Immunol. 2008 Oct 15;181 (8) :5462-72.