RP-182
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs) . RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research[1][2].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; Caspase; NF-κB; TNF Receptor
Related Pathways
Apoptosis; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
Molecular Formula
C69H103N19O11
Molecular Weight
1374.68
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P11108/
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 8; NF-κB
CAS Number
[1895883-60-9]
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
