CCF10
CCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p) ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria[1][2][3].
Product Specifications
CAS Number
116355-81-8
UNSPSC
12352209
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Molecular Formula
C40H67N7O9
Molecular Weight
790.00
References & Citations
[1]Buttaro BA, et al. Cell-associated pheromone peptide (cCF10) production and pheromone inhibition in Enterococcus faecalis. J Bacteriol. 2000 Sep;182 (17) :4926-33.|[2]Zhu L, et al. Pheromone cCF10 inhibits the antibiotic persistence of Enterococcus faecalis by modulating energy metabolism. Front Microbiol. 2024 Jul 8;15:1408701.|[3]Mori M, et al. Structure of cCF10, a peptide sex pheromone which induces conjugative transfer of the Streptococcus faecalis tetracycline resistance plasmid, pCF10. J Biol Chem. 1988 Oct 5;263 (28) :14574-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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