CCF10

CCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p) ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria[1][2][3].

Product Specifications

CAS Number

[116355-81-8]

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Molecular Formula

C40H67N7O9

Molecular Weight

790.00

References & Citations

[1]Buttaro BA, et al. Cell-associated pheromone peptide (cCF10) production and pheromone inhibition in Enterococcus faecalis. J Bacteriol. 2000 Sep;182 (17) :4926-33.|[2]Zhu L, et al. Pheromone cCF10 inhibits the antibiotic persistence of Enterococcus faecalis by modulating energy metabolism. Front Microbiol. 2024 Jul 8;15:1408701.|[3]Mori M, et al. Structure of cCF10, a peptide sex pheromone which induces conjugative transfer of the Streptococcus faecalis tetracycline resistance plasmid, pCF10. J Biol Chem. 1988 Oct 5;263 (28) :14574-8.