Pep-20
Pep-20 is a CD47/SIRPα blocking peptide with KD values of 2.91 and 3.63 μM for human and mouse CD47, respectively. IC50 values for blocking the human and mouse CD47/SIRPα interaction are 24.56 and 12.03 μM, respectively. Pep-20 has antitumor activity[1].
Product Specifications
CAS Number
3056822-31-9
UNSPSC
12352209
Target
CD47
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CNC=N8)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C74H93N21O18
Molecular Weight
1564.66
References & Citations
[1]Wang H, et al. CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy. J Immunother Cancer. 2020 Oct;8 (2) :e000905.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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