PA2-GNU7

PA2-GNU7 is an antimicrobial peptide (AMP) . PA2-GNU7 exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 rapidly and selectively kills Pseudomonas aeruginosa without affecting other commensal bacteria. PA2-GNU7 significantly improves survival of mice infected with P. aeruginosa. PA2-GNU7 can be used for the research and development of therapeutic agents against MDR Pseudomonas aeruginosa infections[1].

Product Specifications

CAS Number

[2387505-19-1]

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(NC(CCC(N)=O)C(NC(CCCNC(N)=N)C(NC(CCCCN)C(NC(CC(C)C)C(NC(C)C(NC(C)C(NC(CCCCN)C(NC(CC(C)C)C(NC(C(O)C)C(NC(CO)C(NC(CCCCN)C(NCC(NCC(NCC(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(CC(C)C)C(NC(CCCNC(N)=N)C(N1C(CCC1)C(NC(CC(C)C)C(N[C@H](CC(C)C)C(NC(CCC(N)=O)C(N[C@H](CC(C)C)C(NC(CC(C)C)C(N[C@H](CCCCN)C(NC(CCC(N)=O)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(CO)N

Molecular Formula

C150H276N50O37

Molecular Weight

3372.11

References & Citations

[1]Kim H, et al. Development of a novel hybrid antimicrobial peptide for targeted killing of Pseudomonas aeruginosa. Eur J Med Chem. 2020 Jan 1;185:111814.