TP53 neoepitope
TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8+ T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) [1].
Product Specifications
CAS Number
[151808-74-1]
UNSPSC
12352209
Target
MHC
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(N[C@@H](CCSC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CNC=N2)N
Molecular Formula
C45H74N16O13S2
Molecular Weight
1111.30
References & Citations
[1]Gurung HR, et al. Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types. Nat Biotechnol. 2024 Jul;42 (7) :1107-1117.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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