APGW-amide

APGW-amide is a neuropeptide. APGW-amide controls the growth of imposex structures and promotes growth in Haliotis asinina. APGW-amide inhibits Achatina neurons and modulates neuronal currents induced by neuroactive compounds. APGW-amide induces a rapid increase in [Ca2+]i in Fura-2/AM-loaded PC12 cells. APGW-amide is useful for research on the nervous system[1][2][3][4].

Product Specifications

CAS Number

[126675-52-3]

UNSPSC

12352209

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N1[C@@H](CCC1)C(NCC(N[C@@H](CC2=CNC3=CC=CC=C23)C(N)=O)=O)=O)[C@H](C)N

Molecular Formula

C21H28N6O4

Molecular Weight

428.48

References & Citations

[1]Han XY, et al. Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: amines and amino acids. Gen Pharmacol. 1997 Oct;29 (4) :523-30.|[2]Han XY, et al. Effect of APGW-amide on [Ca2+]i in rat pheochromocytoma PC12 cells. Jpn J Pharmacol. 2000 Nov;84 (3) :355-9.|[3]Piyachat Chansela, et al. The Tetrapeptide Apgw-Amide Induces Somatic Growth in Haliotis asinina Linnaeus.|[4]Oberdörster E, et al.The neuropeptide APGWamide induces imposex in the mud snail, Ilyanassa obsoleta. Peptides. 2000 Sep;21 (9) :1323-30.