CP-EPS8-NLS

CP-EPS8-NLS is a peptide with anti-AML property. CP-EPS8-NLS interferes with EPS8-associated signaling and exerts anti-AML activity in various AML cell types. CP-EPS8-NLS has potent antitumor activity in xenograft tumor models. CP-EPS8-NLS downregulates EPS8 expression and its downstream pathway[1].

Product Specifications

UNSPSC

12352209

Target

Complement System

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C(C)NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](CO)C(N[C@@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C130H249N61O29

Molecular Weight

3130.76

References & Citations

[1]Chen, Y., et al., (2018) . A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia. Journal of experimental & clinical cancer research : CR, 37 (1), 12.