[Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10)
[Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131) -induced dysfunctional voiding in wild-type mice. [Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research[1].
Product Specifications
CAS Number
[2770688-04-3]
UNSPSC
12352209
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H](C(NCC(N([C@@H](CC(C)C)C(N[C@@H](CCCC)C(N)=O)=O)C)=O)=O)C(C)C)=O)=O)CCCCN)=O
Molecular Formula
C39H65N9O10
Molecular Weight
819.99
References & Citations
[1]Gustafsson M B F, et al. Compounds and their use in treatment of tachykinin receptor mediated disorders. WO2022096736A1. 2022-05-12.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NK2R; NK3R
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