Sakacin P

Sakacin P is an antimicrobial peptide that targets Gram-positive bacteria (such as Listeria monocytogenes) and belongs to Class IIa bacteriocin. Sakacin P has almost no antimicrobial activity against Gram-negative bacteria. Sakacin P exerts its antimicrobial activity by interacting with bacterial cell membranes and destroying membrane integrity. Sakacin P can be used for the study of Listeria contamination and antimicrobial drugs in the food industry.

Product Specifications

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(NCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](C)C(NCC(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%10=O)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC%11=CNC=N%11)C(N[C@H]%10CO)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Molecular Formula

C192H278N60O59S2

Molecular Weight

4434.76

References & Citations

[1]Chang B, et al. Design and Antibacterial Mechanism of Peptides Derived from Sakacin P. Russian Journal of Bioorganic Chemistry, 2022, 48 (2) : 399-410.