IRF5-CPP5
IRF5-CPP5 is a cytosolic peptide that selectively inhibits human IRF5 with IC50 values of 15.4 and 15.3 μM for recombinant S430D or wild-type (WT) IRF5 dimerization, respectively.[1].
Product Specifications
CAS Number
1601299-92-6
UNSPSC
12352209
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
95.38
Smiles
O=C(NC(C)C(NC(CC(N)=O)C(NC(CC(C)C)C(NCC(NC(CC1=CC=C(C=C1)O)C(NC(CC2=CNC3=CC=CC=C23)C(NC(CC(C)C)C(NC(CC(C)C)C(NC(C)C(NC(CC(C)C)C(NC(CC4=CC=CC=C4)C(NC(C(C)C)C(NC(C(O)C)C(NC(CC5=CC=C(C=C5)O)C(NC(CC6=CNC7=CC=CC=C67)C(NC(C(O)C)C(NC(CC(O)=O)C(NC(CC(C)C)C(NCC(NC(CC(C)C)C(NC(C(C)C)C(NC(CCCCN)C(NC(CCCCN)C(NC(CCCNC(N)=N)C(N8C(CCC8)C(NC(CCCCN)C(N9[C@H](CCC9)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(CCSC)N
Molecular Formula
C160H245N37O36S
Molecular Weight
3294.95
References & Citations
[1]Banga J, et al. Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization. Sci Adv. 2020 May 15;6 (20) :eaay1057.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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