A8 peptide
A8 peptide is a Hsp72 antagonist. A8 peptide inhibits tumor progression and metastasis as well as enhances the cancer cells' sensitivity to apoptosis induced by chemotherapeutic agents (such as Cisplatin ) by blocking the Hsp72-TLR2 interaction and the subsequent activation of MDSCs. A8 peptide can be used for cancers research[1].
Product Specifications
CAS Number
1140483-17-5
UNSPSC
12352209
Target
HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC6=CC=C(C=C6)O)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N
Molecular Formula
C48H66N12O12
Molecular Weight
1003.11
References & Citations
[1]Vadevoo SMP, et al. Peptides as multifunctional players in cancer therapy. Exp Mol Med. 2023 Jun;55 (6) :1099-1109.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HSP70
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