SP94

SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research[1][2][3].

Product Specifications

CAS Number

[1158983-49-3]

UNSPSC

12352209

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C([C@H]1N(CCC1)C([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@@H](NC([C@@H](N)CO)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O

Molecular Formula

C65H104N14O16

Molecular Weight

1337.61

References & Citations

[1]Lo A, et al. Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery. Mol Cancer Ther. 2008 Mar;7 (3) :579-89. |[2]Toita R, et al. Development of human hepatocellular carcinoma cell-targeted protein cages. Bioconjug Chem. 2012 Jul 18;23 (7) :1494-501.|[3]Toita R, et al. Development of human hepatocellular carcinoma cell-targeted protein cages. Bioconjug Chem. 2012 Jul 18;23 (7) :1494-501.