P53-hDM2 cyclic peptide inhibitor 16e

P53-hDM2 cyclic peptide inhibitor 16e is a p53-hDM2 cell-permeable peptide inhibitor with an IC50 of 9.24 nM for hDM2. p53-hDM2 cyclic peptide inhibitor 16e can be used for cancers like breast, colorectal and cervical cancers research[1].

Product Specifications

UNSPSC

12352209

Target

MDM-2/p53

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H]2CC3=CC=C(O)C=C3)=O)CCC(O)=O)=O)CSCCCCCCSC[C@H](NC([C@@H](NC2=O)CC4=CNC5=C4C=CC=C5)=O)CNC(N[C@H](CNC(N[C@H](CNC(N)=O)C(C)C)=O)C)=O)=O)=O)[C@H](O)C)[C@H](CCCCN)NC(C)=O

Molecular Formula

C69H102N16O15S2

Molecular Weight

1459.78

References & Citations

[1]Neuville M, et al. Cell-Permeable Peptide Inhibitors of the p53-hDM2 Interaction via Foldamer Helix Mimicry and Bis-Thioether Stapling. J Med Chem. 2025 Jan 9;68 (1) :236-246.