DOTA-TMVP1446

DOTA-TMVP1446 is a VEGFR-3 targeting peptide. DOTA-TMVP1446 labeled with 68Ga accurately detectes the status of lymph node metastasis, even in micrometastatic tumors, in the B16-F10 tumor mice model. DOTA-TMVP1446 can be used as a radiotracer for cancer-metastatic sentinel lymph nodes (m-SLN) imaging[1].

Product Specifications

Product Name Alternative

DOTA-PEG4-TMVP1446

UNSPSC

12352209

Target

VEGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(NCCOCCOCCOCCOCCC(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(NCC(NCC(NCC(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)O

Molecular Formula

C74H134N26O28S

Molecular Weight

1868.08

References & Citations

[1]Yuan Y, et al. Identification of a Novel Vascular Endothelial Growth Factor Receptor-3-Targeting Peptide for Molecular Imaging of Metastatic Lymph Nodes. Bioconjug Chem. 2024 Nov 20;35 (11) :1843-1858.