IS4
IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases[1].
Product Specifications
CAS Number
3067986-23-3
UNSPSC
12352209
Target
Calcium Channel; CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@H](CSC1=C2C(N(CC#C)C1=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CS2)C(O)=O)=O)=O)=O)=O)=O)=O)C
Molecular Formula
C48H62N14O11S2
Molecular Weight
1075.22
References & Citations
[1]Hamshaw I, et al. The development of potent, competitive CXCR4 antagonists for the prevention of cancer metastasis. Biochem Pharmacol. 2023 Dec;218:115921.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR4
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MR200053L4V 200 µL
1810037I17Rik (NM_024461) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details orb1617689 100 µL
Glutathione S-transferase P Polyclonal Conjugated Antibody
Sign In for Pricing
View Details 
![(3aR, 4R, 5R, 6aS) -Hexahydro-5-hydroxy-4-[ (1E, 3R) -3-hydroxy-4-[3- (trifluoromethyl) phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-2-one](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
427850-01 100 mg
(3aR, 4R, 5R, 6aS) -Hexahydro-5-hydroxy-4-[ (1E, 3R) -3-hydroxy-4-[3- (trifluoromethyl) phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-2-one
Sign In for Pricing
View Details 427850-02 250 mg
(3aR, 4R, 5R, 6aS) -Hexahydro-5-hydroxy-4-[ (1E, 3R) -3-hydroxy-4-[3- (trifluoromethyl) phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-2-one
Sign In for Pricing
View Details orb2549605 100 µL
Plasma kallikrein light chain Rabbit Polyclonal Antibody (BF350)
Sign In for Pricing
View Details