DX-236

DX-236 is a macrocyclic peptide with a binding affinity of 1.9 µM to human serum albumin (HSA) . DX-236 can fuse with HSV to prolong its circulation in vivo[1].

Product Specifications

UNSPSC

12352209

Target

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Smiles

O=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N6[C@@H](CCC6)C(N[C@@H](CCC(O)=O)C(NCC(NCC(NCC(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N%11[C@@H](CCC%11)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC%12=CNC=N%12)C(N[C@H]7CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C

Molecular Formula

C164H223N41O47S2

Molecular Weight

3584.90

References & Citations

[1]Wong JYK, et al. Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo. Nat Commun. 2023 Sep 13;14 (1) :5654. doi: 10.1038/s41467-023-41427-y. Erratum in: Nat Commun. 2023 Nov 21;14 (1) :7587.