Onc112

Onc112 is a proline-rich antimicrobial peptide that displays potent activity against Gram-negative bacteria. Onc112 inhibits translation by blocking and destabilizing the initiation complex[1].

Product Specifications

CAS Number

[1273548-87-0]

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CC(N)=O)C(N[C@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

Molecular Formula

C109H177N37O24

Molecular Weight

2389.81

References & Citations

[1]Seefeldt AC, et al. The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat Struct Mol Biol. 2015 Jun;22 (6) :470-5.