Corticostatin, human (TFA)

Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candida albicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients[1][2][3].

Product Specifications

Product Name Alternative

Human Neutrophil Peptide-4 (TFA)

UNSPSC

12352209

Target

Bacterial; SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@H](O)C)C(N[C@H]3CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CSSC[C@@H]1NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NCC(N[C@H]5CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N.O=C(O)C(F)(F)F.[x]

Molecular Formula

C157H255N49O43S6. xC2HF3O2

Molecular Weight

3709.43 (free base)

References & Citations

[1]Ehmann D, et al. Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria. Front Microbiol. 2020 Jun 3;11:1147.|[2]Wilde CG, et al. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem. 1989 Jul 5;264 (19) :11200-3. |[3]Loffredo MR, et al. Antimicrobial peptides for novel antiviral strategies in the current post-COVID-19 pandemic. J Pept Sci. 2024 Jan;30 (1) :e3534.