CT20p
CT20p is an anticancer peptide based on the C hydrophobic terminus of Bax. CT20p has a unique cytotoxic effect independent of full-length Bax, and can act on mitochondria, leading to fusion-like aggregation and mitochondrial membrane hyperpolarization. CT20p can reduce α5β1 integrin levels and inhibit F-actin polymerization, thereby destroying the cytoskeleton and preventing cell attachment. CT20p can be used in the study of breast cancer[1].
Product Specifications
CAS Number
1407967-57-0
UNSPSC
12352209
Target
Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(N[C@@H](C)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Molecular Formula
C103H170N24O25S
Molecular Weight
2176.66
References & Citations
[1]Lee MW, et al. The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption. Cell Death Dis. 2014 May 22;5 (5) :e1249.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Bax
Frequently Asked Questions
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