Buccalin

Buccalin is a neuropeptide that colocalizes with small molecule cardioactive peptides in neuronal B15. When exogenously applied to the ARC neuromuscular junction, Buccalin reduces the amplitude of muscle contraction induced by motor neuron firing and acts only presynaptically. Buccalin has no effect on the rate of muscle relaxation and reduces motor neuron-induced ARC excitatory junction potentials without affecting contraction produced by direct acetylcholine action on the muscle[1].

Product Specifications

CAS Number

[116786-35-7]

UNSPSC

12352209

Target

Neuropeptide S Receptor

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C45H72N12O15S

Molecular Weight

1053.19

References & Citations

[1]Cropper EC, et al. Structure and action of buccalin: a modulatory neuropeptide localized to an identified small cardioactive peptide-containing cholinergic motor neuron of Aplysia californica. Proc Natl Acad Sci U S A. 1988 Aug;85 (16) :6177-81.