NK224

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) [1].

Product Specifications

UNSPSC

12352209

Target

PD-1/PD-L1

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C(CSC[C@H](NC1=O)C(NCC(N)=O)=O)N[C@H](C(N([C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N([C@@H](CCCC)C(N([C@H](C(N[C@H]1CCCCNC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)CCCC)C)=O)C)=O)CC5=CN(CC(O)=O)C6=C5C=CC=C6)=O)CO)=O)CC7=CNC8=CC=CC=C78)=O)C[C@@H](O)C3)=O)CCC(O)=O)=O)CC9=CNC=N9)=O)CCC2)=O)CC(N)=O)=O)C)C)=O)CC%10=CC=C(O)C=C%10

Molecular Formula

C104H145N25O29S

Molecular Weight

2241.48

References & Citations

[1]Zhao L, et al. 68Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study. Clin Cancer Res. 2025 Jul 15;31 (14) :2989-3001.