P9R

P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), A (H1N1) pdm09, A (H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A (H1N1) pdm09 infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research[1].

Product Specifications

CAS Number

[2484874-12-4]

UNSPSC

12352209

Target

Enterovirus; Influenza Virus; SARS-CoV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CS)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N3[C@@H](CCC3)C(N[C@@H](CS)C(N4[C@@H](CCC4)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CS)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N

Molecular Formula

C144H232N52O35S5

Molecular Weight

3412.04

References & Citations

[1]Zhao H, et al. A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. Nat Commun. 2020 Aug 25;11 (1) :4252.