Peptide R analogue 10

Peptide R analogue 10 (compound 10) is an analog of the CXCR4 antagonist peptide Peptide R (HY-P4111) with stronger antagonistic potency, specificity and plasma stability. Peptide R analogue 10 can inhibit CXCL12-mediated cell migration, ERK phosphorylation and CXCR4 internalization. Peptide R analogue 10 can be used in the study of CXCR4 overexpressing leukemia and colon cancer[1].

Product Specifications

CAS Number

[1998129-59-1]

UNSPSC

12352209

Target

CXCR; ERK

Related Pathways

GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C1N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(O)=O)CSSC[C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]1CC3=CC=CC=C3OC4N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(O)=O)CSSC[C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]4CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O

Molecular Formula

C82H118N26O18S4

Molecular Weight

1884.24

References & Citations

[1]Di Maro S, et al. Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12) : Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists. J Med Chem. 2016 Sep 22;59 (18) :8369-80.