RT2
RT2 is a tryptophan-rich cationic amphipathic antibacterial peptide, with main targets including lipopolysaccharide (LPS) on the bacterial surface and intracellular DNA. RT2 binds to bacterial surface LPS, and interacts with cytoplasmic membrane phospholipids, enabling it to rapidly penetrate the bacterial cell membrane and enter the cell, and then bind to components such as DNA in the cytoplasmic membrane, thereby exerting antibacterial effects. RT2 is promising for research of acute and chronic infections caused by planktonic bacteria[1].
Product Specifications
CAS Number
1539295-33-4
UNSPSC
12352209
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CC9=CNC%10=CC=CC=C9%10)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CC%13=CNC%14=CC=CC=C%13%14)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N
Molecular Formula
C126H165N39O20
Molecular Weight
2545.91
References & Citations
[1]Anunthawan T, et al. Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria. Biochim Biophys Acta. 2015 Jun;1848 (6) :1352-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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