KT2

KT2 is a cationic amphipathic antibacterial peptide. KT2 can completely kill cells of E. coli O157:H7. KT2 has potent anti-biofilm activity and prevents biofilm formation of E. coli O157:H7. KT2 significantly binds to bacterial surface LPS and interacts with the lipids of liposomes with great penetration capability into bacterial cells, followed by bond to DNA and other cytoplasmic membrane[1].

Product Specifications

CAS Number

1539295-32-3

UNSPSC

12352209

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CC9=CNC%10=CC=CC=C9%10)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CC%13=CNC%14=CC=CC=C%13%14)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N

Molecular Formula

C126H165N31O20

Molecular Weight

2433.85

References & Citations

[1]Anunthawan T, et al. Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria. Biochim Biophys Acta. 2015 Jun;1848 (6) :1352-8.