CS-VIP 8
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM) . CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia[1].
Product Specifications
UNSPSC
12352209
Target
Histone Methyltransferase; WDR5
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC)C(N[C@H](CC1=CC=CC=C1)C2=O)=O)=O)[C@H](NC(C(C)C)=O)CCNC(C(C=C3F)=CC(F)=C3N=NC4=C(F)C=C(C(NCCN2)=O)C=C4F)=O
Molecular Formula
C43H52F4N12O7
Molecular Weight
924.94
References & Citations
[1]Albert L, et al. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. ACS Cent Sci. 2022 Jan 26;8 (1) :57-66.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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