FAP targeting peptide-PEG2 conjugate

FAP targeting peptide-PEG2 conjugate (Example A1) is the peptide (HY-P10945) and linker conjugate of Unlabeled FXX489 (HY-P10944) . Unlabeled FXX489 is a fibroblast activation protein (FAP) -targeting ligand[1][2].

Product Specifications

CAS Number

[3076328-71-4]

UNSPSC

12352209

Target

Radionuclide-Drug Conjugates (RDCs)

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C([C@@H](NC([C@@H](NC([C@@H](N(C(CNC(CNC([C@]1([H])N(CCC1)C([C@@H](NC([C@@H](NC(CNC2=O)=O)CCCCNC(N3CCN(CC3)CC(O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)C)CC4=CC=CC=C4)=O)CC5=CC=C(C=C5)CNC(COCCOCCN)=O)=O)CCCCCC)N[C@H]2CC6=CNC7=CC=CC=C67

Molecular Formula

C73H102N16O18

Molecular Weight

1491.69

References & Citations

[1]Ravit Geva, et al. Abstract CT112: Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of FXX489 ([177Lu]Lu-NNS309) in patients with pancreatic, lung, breast and colorectal cancers. Cancer Res (2025) 85 (8_Supplement_2) : CT112.|[2]Salvatore BONGARZONE, et al. Fap targeting cyclic peptides and conjugates thereof. WO2025037249A1.