Unlabeled FXX489
Unlabeled FXX489 (NNS309) is a fibroblast activation protein (FAP) -targeting ligand. Unlabeled FXX489 can be labeled with 68Ga and 177Lu and shows anticancer effects. Unlabeled FXX489 can be used for the study of pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), breast cancer (BC), and colorectal cancer (CRC) [1].
Product Specifications
CAS Number
3076330-05-4
Product Name Alternative
NNS309
UNSPSC
12352209
Target
FAP
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
98.52
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(O)CN(CCN(CC1)CC(O)=O)CCN(CCN1CC(NCCOCCOCC(NCC2=CC=C(C[C@H](NC([C@H](CC3=CC=CC=C3)N(C)C(CNC(CNC([C@H]4CCCN4C([C@H](CC(O)=O)NC([C@H](CCCCNC(N5CCN(CC(O)=O)CC5)=O)NC(CN6)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCCCC)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C6=O)=O)=O)C=C2)=O)=O)CC(O)=O
Molecular Formula
C89H128N20O25
Molecular Weight
1878.09
References & Citations
[1]Ravit Geva, et al. Abstract CT112: Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of FXX489 ([177Lu]Lu-NNS309) in patients with pancreatic, lung, breast and colorectal cancers. Cancer Res (2025) 85 (8_Supplement_2) : CT112.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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