Unlabeled FXX489

Unlabeled FXX489 (NNS309) is a fibroblast activation protein (FAP) -targeting ligand. Unlabeled FXX489 can be labeled with 68Ga and 177Lu and shows anticancer effects. Unlabeled FXX489 can be used for the study of pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), breast cancer (BC), and colorectal cancer (CRC) [1].

Product Specifications

CAS Number

[3076330-05-4]

Product Name Alternative

NNS309

UNSPSC

12352209

Target

FAP

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Purity

98.52

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(O)CN(CCN(CC1)CC(O)=O)CCN(CCN1CC(NCCOCCOCC(NCC2=CC=C(C[C@H](NC([C@H](CC3=CC=CC=C3)N(C)C(CNC(CNC([C@H]4CCCN4C([C@H](CC(O)=O)NC([C@H](CCCCNC(N5CCN(CC(O)=O)CC5)=O)NC(CN6)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCCCC)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C6=O)=O)=O)C=C2)=O)=O)CC(O)=O

Molecular Formula

C89H128N20O25

Molecular Weight

1878.09

References & Citations

[1]Ravit Geva, et al. Abstract CT112: Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of FXX489 ([177Lu]Lu-NNS309) in patients with pancreatic, lung, breast and colorectal cancers. Cancer Res (2025) 85 (8_Supplement_2) : CT112.