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VSLRGDTRG (acetate)

VSLRGDTRG acetate is a synthetic peptide containing the RGD motif from cadherin 17 (CDH17), which binds to α2β1 integrin and activates its signaling pathway. VSLRGDTRG acetate promotes the high-affinity conformational change of β1 integrin through the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. VSLRGDTRG acetate can be used in research on cancers expressing CDH17, such as colon cancer and pancreatic cancer[1][2].

Product Specifications

UNSPSC

12352209

Target

ERK; FAK; Integrin

Related Pathways

Cytoskeleton; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Purity

99.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N.CC(O)=O.[x]

Molecular Formula

C38H69N15O14..xC2H4O2

Molecular Weight

960.05 (free base)

References & Citations

[1]Bartolome R A, et al. An RGD motif present in cadherin 17 induces integrin activation and tumor growth[J]. Journal of Biological Chemistry, 2014, 289 (50) : 34801-34814.|[2]Jose Ignacio CASAL ALVAREZ, et al. Agents binding specifically to human cadherin-17, human cadherin-5, human cadherin-6 and human cadherin-20 rgd motif. Patent, WO2016169581A1, 2016-10-27.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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