Ac-DMLD-CMK

Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity[1].

Product Specifications

CAS Number

[2588354-33-8]

UNSPSC

12352209

Target

Caspase; Pyroptosis

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

ClCC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O

Molecular Formula

C22H35ClN4O9S

Molecular Weight

567.05

References & Citations

[1]Shen X, et al. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021 Feb 15;12 (2) :186.